Hemin chloride from porcine
SKU: 02198820-CF
Hemin Chloride
Application Notes
Hemin is used in the management of porphyria attacks, particularly in acute intermittent porphyria.It may be used to study the expression and repression of heme oxygenase 1 (HO-1) as well as the activity of HO-1.Hemin is used for the following applications:• To study bacterial strains and growth conditions• Used in short-term colony assays (the culture medium consists of hemin along with other components)• Cell transfections• It may be used in ß-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
| SKU | 02198820-CF |
| Alternate Names | Hemin Chloride; Chloroferriprotoporphyrin; Chlorohemin; Chloro(protoprophyrinato) iron (III); Ferriprotoporphyrin IX chloride; Hematin hydrochloride; Protohemin IX; (SP-5-13)-Chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N21, N22, N23, N24] ferrate(2-) dihydrogen; Chloro [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2, 18-porphinedipropionato (2-)]iron; 1,3,5,8-tetramethyl-2,4-divinylporphine-6,7- dipropionic acid ferrichloride; Teichmann's crystals; Ferriheme chloride |
| Application Notes | Hemin is used in the management of porphyria attacks, particularly in acute intermittent porphyria.It may be used to study the expression and repression of heme oxygenase 1 (HO-1) as well as the activity of HO-1.Hemin is used for the following applications:• To study bacterial strains and growth conditions• Used in short-term colony assays (the culture medium consists of hemin along with other components)• Cell transfections• It may be used in ß-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin. |
| Base Catalog Number | 198820 |
| Beilstein Registry Number | 5229914 |
| Biochemical Physiological Actions | Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders. Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae. |
| CAS # | 16009-13-5 |
| EC Number | 240-140-1 |
| Format | Powder |
| Molecular Formula | C34H32ClFeN4O4 |
| Personal Protective Equipment | Eyeshields, Gloves,respirator filter |
| Preparation Method | Typically prepared by heating a hemoglobin solution with acetic acid and sodium chloride. |
| Source | Porcine |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| European Extra Text | Temporarily not available in Europe |
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