Polyuridylic acid is an RNA analog, a homopolymer of uridine.
Application Notes
Polyuridylic Acid Potassium Salt is used as a substrate for RNase A. It has also been used in an assay to estimate the concentration of mRNA solutions. May be used to make poly(U)-agarose, which can be used to isolate RNA binding proteins. It has also been used to inhibit the formation of some RNA-protein complexes. It is used as a single-stranded RNA model compound often in comparison with other ssRNA model oligonucleotides such as Poly(I) and Poly(C) to study processes that are dependent upon ssRNA regulation such as Toll-like receptor regulation. Poly(U) is used as an effective agonist for TLR7.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Agonist for TLR7
| SKU | 0210270705 |
| Alternate Names | Poly(U) potassium salt |
| Application Notes | Polyuridylic Acid Potassium Salt is used as a substrate for RNase A. It has also been used in an assay to estimate the concentration of mRNA solutions. May be used to make poly(U)-agarose, which can be used to isolate RNA binding proteins. It has also been used to inhibit the formation of some RNA-protein complexes. It is used as a single-stranded RNA model compound often in comparison with other ssRNA model oligonucleotides such as Poly(I) and Poly(C) to study processes that are dependent upon ssRNA regulation such as Toll-like receptor regulation. Poly(U) is used as an effective agonist for TLR7. |
| Base Catalog Number | 10270705 |
| CAS # | 28086-43-3 |
| Extinction Coefficient | Extinction coefficient: EmM = 9.4 (0.1 M phosphate buffer, pH 7.0)(Lit.) |
| Pack Size | 5 mg |
| Solubility | Soluble in water (20 mg/mL) & 0.1 N KPO<sub>4</sub> buffer, pH 7.0 (10 mg/mL). |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| UV Visible Absorbance | λmax: 260 nm(Lit.) |
![DS [02102707]](https://www.mpbio.com/static/version1783335304/frontend/Mpbio/luma/en_US/images/document.png "DS [02102707]")
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