Acetyl Coenzyme A Trilithium Salt Trihydrate
Application Notes
Acetyl coenzyme A is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. It is a positive regulator of pyruvate carboxylase. It is a percursor of the neurotransmitter acetylcholine.The acetic acid moiety which is bound by a high-energy bond (free energy 34.3 kJ/mol) to the -SH group of coenzyme A is a precursor to fatty acids, steroids and other naturally occurring compounds, such as terpenes and acetogenins present in plants. The biosynthetic pathways for acetyl-CoA have been published.In the transfer reaction by acetyl-CoA of the C2 acetyl fragment, either the carboxyl group or the methyl group may react (electrophilic vs. nucleophilic reaction, respectively).
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Cofactor
| SKU | 02100490-CF |
| Alternate Names | Acetyl-CoA trilithium salt ; Acetyl-CoA; Acetyl-S-CoA Li3; Acetyl CoA Lithium; Acetyl-S-CoA Lithium |
| Application Notes | Acetyl coenzyme A is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. It is a positive regulator of pyruvate carboxylase. It is a percursor of the neurotransmitter acetylcholine.The acetic acid moiety which is bound by a high-energy bond (free energy 34.3 kJ/mol) to the -SH group of coenzyme A is a precursor to fatty acids, steroids and other naturally occurring compounds, such as terpenes and acetogenins present in plants. The biosynthetic pathways for acetyl-CoA have been published.In the transfer reaction by acetyl-CoA of the C2 acetyl fragment, either the carboxyl group or the methyl group may react (electrophilic vs. nucleophilic reaction, respectively). |
| Base Catalog Number | 100490 |
| Biochemical Physiological Actions | Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins. |
| CAS # | 75520-41-1 |
| EC Number | 200-790-9 |
| Extinction Coefficient | EM:(260 nm): 16,400 (water) , (259): 15,400 (0.1 M PO4 buffer, pH 7) , (232 nm): 8,700 (water) (Lit.) |
| Format | Powder |
| Hazard Statements | H315-H319-H335 |
| Molecular Formula | C23H35Li3N7O17P3S·3H2O |
| Molecular Weight | 881.1 g/mol |
| Personal Protective Equipment | Dust mask , Eyeshields, Gloves |
| Purity | >90% |
| Safety Symbol | GHS07 |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| UV Visible Absorbance | λ max (0.1N HCl) : 258 ± 4 nm |
