Cefotaxime, sodium salt, phytopure™
SKU: 02154947-CF
A cephalosporin antibiotic effective against gram-positive and gram-negative bacteria. It interferes with cell wall formation by inhibiting cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls. Useful in plant cell culture because it doesn't affect the plasmids of developed vascular plants.
Application Notes
Cefotaxime is used for infections of the respiratory tract, skin, bones, joints, urogenital system, meninges, and bloodstream. It generally has good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas. It is also effective against most Gram-positive cocci except for Enterococcus. It is active against penicillin-resistant strains of Streptococcus pneumoniae. It has modest activity against the anaerobic Bacteroides fragilis. In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Cell wall inhibitor
| SKU | 02154947-CF |
| Alternate Names | Cefotaxime sodium; (6R-(6-a,7-b(Z)))-3-((Acetyloxy) methyl)-7- (((2-amino-4-thiazolyl) (methoxyimio) acetyl) amino)-8- oxo-5-thia-1- azabicyclo (4,2,0) oct-2-ene-2-carboxylic acid, sodium salt |
| Application Notes | Cefotaxime is used for infections of the respiratory tract, skin, bones, joints, urogenital system, meninges, and bloodstream. It generally has good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas. It is also effective against most Gram-positive cocci except for Enterococcus. It is active against penicillin-resistant strains of Streptococcus pneumoniae. It has modest activity against the anaerobic Bacteroides fragilis. In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime. |
| Base Catalog Number | 154947 |
| Beilstein Registry Number | 5711411 |
| Biochemical Physiological Actions | Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes. |
| CAS # | 64485-93-4 |
| EC Number | 264-915-9 |
| Hazard Statements | H317-H334 |
| Molecular Formula | C16H16N5O7S2Na |
| Molecular Weight | 477.40 |
| Personal Protective Equipment | Dust mask, Eyeshields, Faceshields, Gloves |
| Purity | ≥95% |
| RTECS Number | XI0250000 |
| Safety Symbol | GHS08 |
| Solubility | 68.2 [ug/mL] |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![MP COA [154947] lot ID: 94858](https://www.mpbio.com/static/version1780565991/frontend/Mpbio/luma/en_US/images/document.png "MP COA [154947] lot ID: 94858")
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