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Product Description
Phorbol-12-Myristate-13-Acetate
Application Notes
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Very Potent tumor promoter
Specifications
SKU | 02151864-CF |
Alternate Names | Phorbol Acetate Myristate; Phorbol Monoacetate Monomyristate; PMA; 12-O-Tetradecanoylphorbol 13-acetate; 4,9,12,13,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; TPA |
Application Notes | PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. |
Base Catalog Number | 151864 |
Beilstein Registry Number | 2407201 |
Biochemical Physiological Actions | Potent tumor promoter; activates protein kinase C in vivo and in vitro. |
CAS # | 16561-29-8 |
Hazard Statements | H315 |
Melting Point | 162° F (NTP, 1992) |
Molecular Formula | C36H56O8 |
Molecular Weight | 616.836 g/mol |
Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
Purity | 99% |
RTECS Number | QH4377000 |
Safety Symbol | GHS07 |
Solubility | Practically insoluble (NTP, 1992) |
Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Vapor Pressure | 1.8X10-17 mm Hg at 25 deg C (est) |
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