MP Biomedicals Saliva Panel Test
Available formats
Test Cassette
Test Cup
Available Parameters
Amphetamine (AMP)
Amphetamine (amphetamine, methamphetamine, and the structurally related “designer” drugs, e.g., “Ecstasy”) are sympathomimetic amines whose biological effects include potent central nervous system (CNS) stimulation, anorectic, hyperthermic, and cardiovascular properties. They are usually taken orally, intravenously, or by smoking. Amphetamines are readily absorbed from the gastrointestinal tract and are then either deactivated by the liver. Amphetamines increase the heart rate and blood pressure and suppress the appetite. Some studies indicate that heavy abuse may result in permanent damage to certain essential nerve structures in the brain.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 min
Benzodiazepine (BZD)
Benzodiazepine are medications that are frequently prescribed for the symptomatic treatment of anxiety and sleep disorders. They produce their effects via specific receptors involving a neurochemical called gamma aminobutyric acid (GABA). Because they are safer and more effective, Benzodiazepines have replaced Barbiturates in the treatment of both anxiety and insomnia. Benzodiazepines are also used as sedatives before some surgical and medical procedures, and for the treatment of seizure disorders and alcohol withdrawal.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Barbiturate (BAR)
Barbiturate are central nervous system depressants. They are used therapeutically as sedatives, hypnotics, and anticonvulsants. Barbiturates are almost always taken orally as capsules or tablets. The effects resemble those of intoxication with alcohol. Chronic use of Barbiturates leads to tolerance and physical dependence. Short acting Barbiturates taken at 400 mg/day for 2-3 months produce a clinically significant degree of physical dependence. Withdrawal symptoms experienced during periods of drug abstinence can be severe enough to cause death.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Buprenorphine (BUP)
Buprenorphine is a potent analgesic often used in the treatment of opioid addiction. Therapeutically, Buprenorphine is used as a substitution treatment for opioid addicts. Substitution treatment is a form of medical care offered to opiate addicts (primarily heroin addicts) based on a similar or identical substance to the drug normally used. In substitution therapy, Buprenorphine is as effective as Methadone but demonstrates a lower level of physical dependence. Concentrations of free Buprenorphine and Norbuprenorphine in saliva may be less than 1 ng/mL after therapeutic administration but can range up to 20 ng/mL in abuse situations. The plasma half-life of Buprenorphine is 2-4 hours. While complete elimination of a single dose of the drug can take as long as 6 days, the detection window for the parent drug in urine is thought to be approximately 3 days.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Cocaine (COC)
Cocaine derived from leaves of the coca plant, cocaine is a potent central nervous system stimulant and a local anesthetic. Among the psychological effects induced by using cocaine are euphoria, confidence and a sense of increased energy, accompanied by increased heart rate, dilation of the pupils, fever, tremors and sweating. Cocaine is excreted in saliva primarily as benzoylecgonine in a short period of time.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Cotinine (COT)
Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which virtually every member of a tobacco-smoking society is exposed whether through direct contact or second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches and nasal sprays.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Ketamine (KET)
Ketamine is a derivative of phencyclidine. It is used medically as a veterinary and human anesthetic since 1970. About 90 percent of the ketamine legally sold is intended for veterinary use. It can be injected or snorted but is sometimes sprinkled on tobacco or marijuana and smoked. Ketamine is frequently used in combination with other drugs, such as ecstasy, heroin or cocaine. Ketamine is also known as "special K" or "vitamin K." Certain doses of Ketamine can cause dream-like states and hallucinations. In high dose, ketamine can cause delirium, amnesia, impaired motor function, high blood pressure, depression, and potentially fatal respiratory problems. Ketamine is metabolized in the liver and excreted through the kidney.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Methamphetamine (M-AMP)
Methamphetamine and its metabolites are potent sympathomimetic agents. Acute higher doses lead to enhanced stimulation of the central nervous system and symptoms include euphoria, alertness, and a sense of increased energy and power. More acute responses produce anxiety, paranoia, psychotic behavior, and cardiac dysrhythmias. The pattern of psychosis which may appear at high doses may be indistinguishable from schizophrenia.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
MDMA
MDMA is an abbreviation for the chemical methylenedioxymethamphetamine MDMA. It has street many names including Ecstasy, X, XTC, E, Love Doves, Clarity, Adam, Disco Biscuits and Shamrocks, etc. it is a stimulant with hallucinogenic tendencies, described as an empathogen as it releases mood-altering chemicals, such as cartooning and L-dopa, in the brain and may generate feelings of love and friendliness. MDMA is a Class A drug, in the same category as heroin and cocaine. The adverse effects of MDMA use include elevated blood pressure, hyperthermia, anxiety, paranoia, and insomnia.
Overdoses of MDMA can be fatal, often resulting in heart failure or heart stoke.
MDMA belongs to a family of man-made drugs; its relatives include MDA (methylenedioxy MDMA), the parent drug of MDMA, and MDEA (methylenedioxyethyl MDMA), also known as EVE. They all share the MDMA-like effects. MDMA is administered either by oral ingestion or intravenous injection. MDMA tablets come in different sizes and colors, and often have logos such as doves on them. Its clinical dose is 50-100mg; the threshold toxic dose is 500mg. The effects of MDMA begin 30 minutes after intake. They peak in an hour and last for 2-3 hours. it is detectible in the saliva for up to 3 days after use.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Methadone (MTD)
Methadone is a synthetic analgesic drug that is originally used in the treatment of narcotic addicts. Among the psychological effects induced by using methadone are analgesia, sedation and respiratory depression. Overdose of methadone may cause coma or even death. It is administered orally or intravenously and is metabolized in the liver. The kidneys are a major route of methadone excretion.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Opiates (OPI)
Opiates such as heroin, morphine, and codeine are derived from the resin of opiu m poppy. Heroin is quickly metabolized to morphine. Thus, morphine and morphine glucuronide might both be found in the saliva of a person who has taken only heroin. The body also changes codeine to morphine. Thus, the presence of morphine (or the metabolite, morphine glucuronide) in the saliva often indicates heroin, morphine and/or codeine use.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Oxycodone (OXY)
Oxycodone is a semi-synthetic opioid with a structural similarity to codeine. The drug is manufactured by modifying thebaine, an alkaloid found in the opium poppy. Oxycodone, like all opiate agonists, provides pain relief by acting on opioid receptors in the spinal cord, brain, and possibly directly in the affected tissues. Oxycodone is known to metabolize by demethylation into oxymorphone and noroxycodone.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Phencyclidine (PCP)
Phencyclidine is an arylcyclohexylamine that was originally used as an anesthetic agent and a veterinary tranquilizer. Phencyclidine can produce hallucinations, lethargy, disorientation, loss of coordination, trance-like ecstatic states, a sense of euphoria and visual distortions. It has many street names, such as “angel dust” and “crystal cyclone”, etc. Phencyclidine can be administered orally, by nasal ingestion, smoking, or intravenous injection. It is metabolized in the liver and excreted through the kidneys.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Marijuana (THC)
THC Tetrahydrocannabinol, the active ingredient in the marijuana plant (cannabis sativa), is detectable in saliva shortly after use. The detection of the drug is thought to be primarily due to the direct exposure of the drug to the mouth (oral and smoking administrations) and the subsequent sequestering of the drug in the buccal cavity. Historical studies have shown a window of detection for THC in saliva of up to 14 hours after drug use.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Tramadol (TML)
Tramadol is a quasi-narcotic analgesic used in the treatment of moderate to severe pain. It is a synthetic analog of codeine but has a low binding affinity to the mu-opioid receptors. Large doses of tramadol can develop tolerance and physiological dependency and lead to its abuse. Tramadol is extensively metabolized after oral administration. Approximately 30% of the dose is excreted in the urine as unchanged drug, whereas 60% is excreted as metabolites. The major pathways appear to be N- and O- demethylation, glucoronidation or sulfation in the liver.
The following table lists the concentrations of compounds (ng/mL) above which the Saliva Panel Test Cassette identified positive results at 10 minutes.
Alcohol
Alcohol intoxication can lead to loss of alertness, coma, and death as well as birth defects. The BAC at which a person becomes impaired is variable. The United States Department of Transportation (DOT) has established a BAC of 0.02% (0.02g/dL) as the cut-off level at which an individual is considered positive for the presence of alcohol.
The Saliva Panel Test Cassette identify
