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Product Description
Amphotericin B
Application Notes
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
Specifications
| SKU | 02195043-CF |
| Alternate Names | Amphomoronal; Amphotericine B; Amphozone; Fungilin; Fungisone; Fungizone |
| Application Notes | Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement. |
| Base Catalog Number | 195043 |
| Beilstein Registry Number | 78342 |
| Biochemical Physiological Actions | Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death. Antimicrobial spectrum: fungi and yeast. Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast |
| CAS # | 1397-89-3 |
| EC Number | 215-742-2 |
| Hazard Statements | H315-H319-H335 |
| Melting Point | greater than 338° F (decomposes) (NTP, 1992) |
| Molecular Formula | C47H73NO17 |
| Molecular Weight | 924.091 g/mol |
| Personal Protective Equipment | dust mask , Eyeshields, Gloves |
| pKa | 5.5 and 10.0.(Lit.) |
| Potency | >800 µg/mg |
| RTECS Number | BU2625000 |
| Safety Symbol | GHS07 |
| Solubility | less than 1 mg/mL at 70° F (NTP, 1992) |
| Source | Streptomyces sp. |
| Sterilization of Solutions | Sterilization of solutions should be by filtration through teflon membrane filters; Amphotericin B should not be gamma irradiated or autoclaved. |
| Typical Working Concentration | recommended concentration of 2.5 ug/L (prepared solution use 10 mL/L) |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Documents
![MP COA [195043] lot ID: 1217H](https://www.mpbio.com/static/version1655798373/frontend/Mpbio/default/en_US/images/document.png "MP COA [195043] lot ID: 1217H")