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13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Anti-inflammatory | Anti-tumor
|Application Notes||13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.|
|Base Catalog Number||156518|
|Biochemical Physiological Actions||The action of 13-cis-Retinoic acid (RA) is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.|
|Melting Point||372 to 374Â° F (NTP, 1992)|
|Molecular Weight||300.442 g/mol|
|Personal Protective Equipment||Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter|
|Safety Symbol||GHS07, GHS08|
|Solubility||less than 1 mg/mL at 72Â° F (NTP, 1992)|
|Usage Statement||Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.|
|UV Visible Absorbance||λ max (ethanol): 354 ± 3 nm|
|Vapor Pressure||1.0X10-7 mm Hg @ 25 deg C /Estimated/|