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Vinblastine Sulfate is used in cancer research.
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Used in cancer research
|Alternate Names||VLB; Vincaleukoblastine sulfate salt|
|Application Notes||Vinblastine Sulfate is used in cancer research.|
|Base Catalog Number||190287|
|Beilstein Registry Number||3659812|
|Biochemical Physiological Actions||Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.|
|Melting Point||543 to 545° F (NTP, 1992)|
|Molecular Weight||909.061 g/mol|
|Safety Symbol||GHS05, GHS07|
|Solubility||greater than or equal to 10 mg/mL at 76.1° F (NTP, 1992)|
|Usage Statement||Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.|