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Cancer Research

Your one-stop shop for high-quality reagents to accelerate cancer research.

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Immunology & Cell Biology

Full range of cell culture media and supplements to meet all your research needs from cell structure to life cycle.

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Antibiotics for Cell Culture

Quick reference guide to help you select the right antibiotic for your cell culture experiments.

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New Zealand Bovine Proteins

Learn more about our chromatographically extracted proteins under cGMP quality systems.

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Featured Application: Modeling intestinal inflammation with DSS

Animal models are an essential component of inflammatory bowel disease research (IBD), with chemically induced murine models among the most commonly used due to their simplicity and the ability to control onset, duration, and the severity of inflammation. Both dextran sodium sulfate (DSS) and trinitrobenzene sulfonic acid (TNBS-) induced colitis are well-established murine models of mucosal inflammation that have been used for over 2 decades in preclinical studies and to study IBD pathogenesis. Studies validating DSS models using various therapeutic agents for human IBD have shown that DSS-induced colitis can be used as a relevant model for the translation of mice data to human disease.

The DSS supplied by MP Bio is considered the gold standard for generating murine models of colitis. Download our dosing guide to see recommended doses for different strains of rats and mice, and order DSS today.

Modeling intestinal inflammation with DSS