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Veratridine, 10 mg
It has been used as an insecticide, acting as a paralytic agent with higher toxicity to insects than to mammals. It is also used to increase membrane sodium permeability. It has been used to study Na+ channel blockers such as vincamine and vincanol by inducing Na+ channels in the presence and absence of the drugs being tested.
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|Alternate Names||4,9-Epoxycevane-3, 4, 12, 14, 16, 17, 20-Heptol-3-(3, 4-Dimethoxybenzoate); 3-Veratroylveracevine; (3β, 4α,16β)-4,9-epoxycevane- 3, 4, 12, 14, 16, 17, 20-heptol 3-(3,4-dimethoxybenoate)|
|Application Notes||It has been used as an insecticide, acting as a paralytic agent with higher toxicity to insects than to mammals. It is also used to increase membrane sodium permeability. It has been used to study Na+ channel blockers such as vincamine and vincanol by inducing Na+ channels in the presence and absence of the drugs being tested.|
|Base Catalog Number||15900710|
|Beilstein Registry Number||78875|
|Biochemical Physiological Actions||Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue. Veratridine is cytotoxic to chromaffin cells in vitro.|
|Melting Point||180 DEG C|
|Molecular Weight||673.8 g/mol|
|Optical Rotation||+4.9° (25 mg/mL, ethanol, 25°C(Lit.)|
|Pack Size||10 mg|
|Personal Protective Equipment||Dust mask, Eyeshields, Faceshields, Gloves, respirator cartridges|
|Safety Symbol||GHS06, GHS08|
|Solubility||SOL IN <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/WATER">WATER</a>; SLIGHTLY SOL IN ETHER|
|UV Visible Absorbance||262 nm (ethanol)(Lit.)|