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(±)-Verapamil hydrochloride

(±)-Verapamil hydrochloride

Synonyms Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile; α-isopropyl-α-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile

CAS Number: 152-11-4 Molecular Formula: C27H38N2O4·HCl

Beilstein Registry Number: 3647093 EC Number: 205-800-5 MDL Number: MFCD00055208

SKU 02195545-CF
$80.60
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Description

Product Description

(±)-Verapamil Hydrochloride

Application Notes

(±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Coronary vasodilator

Specifications
SKU 02195545-CF
Alternate Names Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile; α-isopropyl-α-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile
Application Notes (±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.
Base Catalog Number 195545
Beilstein Registry Number 3647093
Biochemical Physiological Actions Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
CAS # 152-11-4
EC Number 205-800-5
Extinction Coefficient EmM = 16.1 (232 nm in ethanol); 6.1 (280 nm in ethanol)(Lit.)
Format Powder
Hazard Statements H301-H311-H331
Molecular Formula C27H38N2O4·HCl
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator cartridge
pKa 8.6 (Lit.)
RTECS Number YV8320000
Safety Symbol GHS06
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.