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Thrombin, high purity grade, ≥1500 NIH U/mg protein

Thrombin, high purity grade, ≥1500 NIH U/mg protein

$66.65

Key features and details

  • Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B
  • Thrombin is prepared from fresh bovine plasma by an ion exchange method
  • Thrombin solution is clarified by centrifugation and filtration and then lyophilized

SKU: 02154163-CF

Synonyms
Factor IIa
CAS Number:
2594047
EC Number:
232-648-7
MDL Number:
MFCD00166053
Product Description

Thrombin

Application Notes

α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Research tool | Medicine | Surgery | Food Industry

Specifications
SKU 02154163-CF
Alternate Names Factor IIa
Application Notes α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.
Base Catalog Number 154163
Biochemical Physiological Actions Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.
CAS # 2594047
EC Number 232-648-7
Grade High Purity
Hazard Statements H315-H319-H334-H335
RTECS Number XO8950000
Safety Symbol GHS07, GHS08
Source Bovine
Specific Activity ≥1500 NIH u/mg protein
Unit Definition The unit defined by the U.S. standard and is approximately equal to the stated unitage. A U.S. unit is defined as the amount required to clot 1 mL of standardized fibrinogen solution in 15 seconds. Approximately 2 U.S. units are required to clot 1 ml of oxalated human plasma in the same period of time. U.S units = NIH units.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Citations
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Datasheet

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