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Tetracycline, hydrochloride

Tetracycline, hydrochloride

Synonyms Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin; Achromycin V; Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324

CAS Number: 64-75-5 Molecular Formula: C22H24N2O8·HCl Molecular Weight: 480.898 g/mol

Beilstein Registry Number: 3844873 EC Number: 200-593-8 MDL Number: MFCD00078142

SKU 02103011-CF
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Description

Product Description

Tetracycline Hydrochloride

Application Notes

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Specifications
SKU 02103011-CF
Alternate Names Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin; Achromycin V; Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324
Application Notes Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis.
Base Catalog Number 103011
Beilstein Registry Number 3844873
Biochemical Physiological Actions Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
CAS # 64-75-5
EC Number 200-593-8
Extinction Coefficient EMm (220nm) = 13 (free base in 0.1 M HCl); EmM (268nm) = 18.04 (free base in 0.1 M HCl); EmM (355nm) = 13.32 (free base in 0.1 M HCl)(Lit.)
Format Powder
Hazard Statements H315-H319-H335
Melting Point 417° F (decomposes) (NTP, 1992)
Molecular Formula C22H24N2O8·HCl
Molecular Weight 480.898 g/mol
Optical Rotation -239 ° to -258 ° (c=0.01, 0.1 N HCl)
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH 3.0-7.0 /saturated solution/
pKa (50% aq DMF): 8.3, 10.2 (Lit.)
Potency ≥900 µg/mg
RTECS Number QI9100000
Safety Symbol GHS07
Solubility 50 to 100 mg/mL at 72° F (NTP, 1992)
Typical Working Concentration 10 mg/L
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λ max (1N HCl) 219, 271, 357 ± 5 nm