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Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition. It inhibits gram-negative and gram-positive bacteria.
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|Alternate Names||Streptomycin Sesquisulfate; O-2-Deoxy-2-(methylamino)-a-L- glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L- lyxofuranosyl- (1->4)- N,N'- bis(aminoiminomethyl)-D-streptamine; Streptomycin A|
|Application Notes||Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition. It inhibits gram-negative and gram-positive bacteria.|
|Base Catalog Number||100556|
|Beilstein Registry Number||3894995|
|Biochemical Physiological Actions||Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.|
|Half Life||half-life in plasma is about 2-4 hours|
|Molecular Weight||1457.376 g/mol|
|Optical Rotation||-77 to -79 ° (c=1% in H2O, 25 °C) (lit.)|
|Personal Protective Equipment||Dust mask, Eyeshields, Faceshields, Gloves|
|Safety Symbol||GHS07, GHS08|
|Solubility||greater than or equal to 0.1 mg/mL at 64Â° F (NTP, 1992)|
|Specific Activity||≥650 u/mg|
|Typical Working Concentration||Typically used at a concentration of 50-100 mg/liter|