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Retinol (all trans)
Retinoic Acid, All Trans Isomer
Retinoic Acid has been used in various differentiation protocols, including B-cells, T cells and neurons and applied clinically to treat cancer as a form of differentiation-induction therapy.
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Signaling molecule | Cancer Research
|Alternate Names||Vitamin A acid; Tretinoin; ATRA; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8 -nonatetraenoic acid; Aberel; Airol; Aknoten; Cordes Vas; Dermairol; Retin-A; Vesnaroid|
|Application Notes||Retinoic Acid has been used in various differentiation protocols, including B-cells, T cells and neurons and applied clinically to treat cancer as a form of differentiation-induction therapy.|
|Base Catalog Number||190269|
|Beilstein Registry Number||2057223|
|Biochemical Physiological Actions||All−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.|
|Melting Point||354 to 360° F (NTP, 1992)|
|Molecular Weight||300.442 g/mol|
|Personal Protective Equipment||Dust mask, Eyeshields, Gloves|
|Solubility||less than 1 mg/mL at 77° F (NTP, 1992)|
|UV Visible Absorbance||λ max (isopropanol + sulfuric acid)=353 ± 3 nm|
|Vapor Pressure||2.4X10-7 mm Hg @ 25 deg C /Estimated/|