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Prostaglandin E2, γ-irradiated, ≥99%, 1 mg
Prostaglandin E2 is use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
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Study of prostaglandin regulated cell signaling and gene regulation
|Alternate Names||[5Z,11a,13E,15S]-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; PGE2; Dinoprostone|
|Application Notes||Prostaglandin E2 is use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.|
|Base Catalog Number||19457601|
|Beilstein Registry Number||4709356|
|Biochemical Physiological Actions||Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.|
|Melting Point||67 °C|
|Molecular Weight||352.471 g/mol|
|Pack Size||1 mg|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge,respirator filter|
|Safety Symbol||GHS07, GHS08|
|Solubility||Water Solubility58.1 mg/L|