Enjoy 30% off select life science products with free shipping and giveaways with promo code: RESEARCH30 Offer ends October 2, 2020.
Prostaglandin E2, γ-irradiated, ≥99%
Prostaglandin E2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation.
Induces cervical ripening and parturition
|Alternate Names||5Z,11α,13E,15S]-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; Dinoprostone; PGE2|
|Application Notes||Prostaglandin E2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation.|
|Base Catalog Number||195461|
|Beilstein Registry Number||4709356|
|Biochemical Physiological Actions||Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.|
|Melting Point||67 °C|
|Molecular Weight||352.471 g/mol|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator filter, respirator cartridges|
|Safety Symbol||GHS07, GHS08|
|Solubility||Water Solubility58.1 mg/L|