A polyene antifungal effective against molds, fungi and yeast contamination. It binds to ergosterol and creates nystatin/ergosterol based ion channels in lipid bilayers causing K+ leakage that results in fungal cell death.
Nystatin is a polyene antibiotic. Its uses include preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in TLR2-expressing THP1 cells.
|Application Notes||Nystatin is a polyene antibiotic. Its uses include preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in TLR2-expressing THP1 cells.|
|Base Catalog Number||194534|
|Biochemical Physiological Actions||Mode of Action: Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.Antimicrobial spectrum: Neomycin acts against fungi, yeasts and molds.|
|Grade||Cell Culture Grade|
|Personal Protective Equipment||Eyeshields, Gloves, Respirator filter|
|Specific Activity||>5000 u/mg|
|Typical Working Concentration||50 mg/L for yeasts and fungi.|
|UV Visible Absorbance||290, 305, 320 ± 2 nm( λ max (ethanol))|