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Naloxone hydrochloride

Naloxone hydrochloride

$39.20
Naloxone Hydrochloride

SKU: 02190245-CF

Synonyms
Narcan; EN-1530; (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride; 17-allyl-4,5α- epoxy-3,14-dihydroxymorphinan-6-one hydrochloride; (-)-N-allyl-14- hydroxynordihydromorphinone; N-allylnoroxymorphone;
CAS Number:
357-08-4
Molecular Formula:
C19H21NO4 • HCl
Beilstein Registry Number:
6260807
EC Number:
206-611-0
Product Description

Naloxone Hydrochloride

Application Notes

The role of naloxone (1 µM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100 µM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors. Naloxone has also been utilized to modulate the NMDA receptor activation capability of the µ-opioid receptor agonist DAMGO.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Opiate antagonist

Specifications
SKU 02190245-CF
Alternate Names Narcan; EN-1530; (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride; 17-allyl-4,5α- epoxy-3,14-dihydroxymorphinan-6-one hydrochloride; (-)-N-allyl-14- hydroxynordihydromorphinone; N-allylnoroxymorphone;
Application Notes The role of naloxone (1 µM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100 µM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors. Naloxone has also been utilized to modulate the NMDA receptor activation capability of the µ-opioid receptor agonist DAMGO.
Base Catalog Number 190245
Beilstein Registry Number 6260807
Biochemical Physiological Actions Naloxone has an extremely high affinity for μ-opioid receptors in the central nervous system. Naloxone is a μ-opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Naloxone also has an antagonist action, though with a lower affinity, at κ- and δ-opioid receptors.
CAS # 357-08-4
EC Number 206-611-0
Format Crystalline powder
Hazard Statements H315-H319-H335
Molecular Formula C19H21NO4 • HCl
Personal Protective Equipment Dust mask, Eyeshields, Gloves
RTECS Number QD2275000
Safety Symbol GHS07
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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