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Guanidine thiocyanate

Guanidine thiocyanate

Synonyms Guanidinium rhodanide; Guanidinium thiocyanate

CAS Number: 593-84-0 Molecular Formula: CH5N3 • HSCN Molecular Weight: 118.158 g/mol

Beilstein Registry Number: 3563461 EC Number: 209-812-1 MDL Number: MFCD00013027

SKU 04820991-CF
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Description

Product Description

Guanidine Thiocyanate

Application Notes

Guanidine Thiocyanate is often used in the isolation of intact ribonucleic acid to eliminate RNase activity. A 4 M solution of guanidine thiocyanate irreversibly inactivates RNase. In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Strong denaturant

Specifications
SKU 04820991-CF
Alternate Names Guanidinium rhodanide; Guanidinium thiocyanate
Application Notes Guanidine Thiocyanate is often used in the isolation of intact ribonucleic acid to eliminate RNase activity. A 4 M solution of guanidine thiocyanate irreversibly inactivates RNase. In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.
Base Catalog Number 820991
Beilstein Registry Number 3563461
CAS # 593-84-0
EC Number 209-812-1
Format Crystalline Granules
Grade Research grade
Hazard Statements H302 + H312 + H332-H314-H412, Contact with acids liberates very toxic gas.
Molecular Formula CH5N3 • HSCN
Molecular Weight 118.158 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Purity >98%
Safety Symbol GHS05, GHS07
Sterilization of Solutions Solutions can be sterilized by filtration using a 0.2 µm filter.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance OD280 (6 M aq soln): <0.5