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Iron storage protein that plays a key role in iron metabolism
|Base Catalog Number||151119|
|Biochemical Physiological Actions||A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.|
|Formulation Details||In 150 mM NaCl; 0.002% sodium azide|
|Molecular Weight||289.498 g/mol|