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Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.
Potent inhibitor of actin polymerization
|Alternate Names||Zygosporin A; 3-Benzyl-3,3-alpha, 4, 5, 6, 6-alpha, 9, 10, 12, 15-Decahydro-6, 12, 15-Trihydroxy-4, 10, 12-Trimethyl-5-Methylene-1H-Cycloundec(d)isoindole-1, 11(2H) Dione, 15-Acetate|
|Application Notes||Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.|
|Base Catalog Number||150771|
|Beilstein Registry Number||1632828|
|Biochemical Physiological Actions||Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.|
|Melting Point||491 to 500Â° F (decomposes) (NTP, 1992)|
|Molecular Weight||507.627 g/mol|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator filter, respirator cartridges|
|Safety Symbol||GHS06, GHS08|