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Cyclophosphamide monohydrate

Cyclophosphamide monohydrate

Synonyms Endoxan A; Cytoxan; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; N,N-bis(2-Chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate; 2-[bis(2-Chloroethyl) amino] tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate; 1-bis(2-Chloroethyl) amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate; bis(2-Chloroethyl) phosphamide cyclic propanolamide ester monohydrate; bis(2-Chloroethyl)phosphoramide cyclic propanolamide ester monohydrate; N,N-bis(b-Chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate; N,N-bis(b-Chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate; Cyclophosphane; Cytophosphane; B-518

CAS Number: 6055-19-2 Molecular Formula: C7H15Cl2N2O2P · H2O Molecular Weight: 279.098 g/mol

Beilstein Registry Number: 4678992 EC Number: 200-015-4 MDL Number: MFCD00149395

SKU 02150749-CF
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Description

Product Description

Cyclophosphamide Monohydrate

Application Notes

Cyclophosphamide monohydrate used for induction chemotherapy to study predictive and prognostic values of tumor MGMT gene expression, to study its effects on apoptosis and cell cycle progression and its cardiotoxicity during pretransplant conditioning in blood stem cell transplantation has been reported.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Cancer research tool

Specifications
SKU 02150749-CF
Alternate Names Endoxan A; Cytoxan; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; N,N-bis(2-Chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate; 2-[bis(2-Chloroethyl) amino] tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate; 1-bis(2-Chloroethyl) amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate; bis(2-Chloroethyl) phosphamide cyclic propanolamide ester monohydrate; bis(2-Chloroethyl)phosphoramide cyclic propanolamide ester monohydrate; N,N-bis(b-Chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate; N,N-bis(b-Chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate; Cyclophosphane; Cytophosphane; B-518
Application Notes Cyclophosphamide monohydrate used for induction chemotherapy to study predictive and prognostic values of tumor MGMT gene expression, to study its effects on apoptosis and cell cycle progression and its cardiotoxicity during pretransplant conditioning in blood stem cell transplantation has been reported.
Base Catalog Number 150749
Beilstein Registry Number 4678992
Biochemical Physiological Actions Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
CAS # 6055-19-2
EC Number 200-015-4
Flash Point greater than 230° F (NTP, 1992)
Hazard Statements H301-H350
Melting Point 121 to 127° F (NTP, 1992)
Molecular Formula C7H15Cl2N2O2P · H2O
Molecular Weight 279.098 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Purity ≥98%
RTECS Number RP6157750
Safety Symbol GHS06, GHS08
Solubility 10 to 50 mg/mL at 73° F (NTP, 1992)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.