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Cycloheximide is used in protein synthesis in apoptosis. It is also used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production.
Gene expression | steroidogenesis Studies | Disease resistance Studies
|Alternate Names||Acti-Dione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl] glutarimide; Naramycin A; Actidione|
|Application Notes||Cycloheximide is used in protein synthesis in apoptosis. It is also used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production.|
|Base Catalog Number||100183|
|Beilstein Registry Number||88868|
|Biochemical Physiological Actions||Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.|
|Melting Point||247 to 250° F (EPA, 1998)|
|Molecular Weight||281.352 g/mol|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type , Gloves, respirator cartridge, respirator filter, respirator cartridges|
|Safety Symbol||GHS06, GHS08|
|Solubility||10 to 50 mg/mL at 68° F (NTP, 1992)|