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Collagen, Type I from calf skin

Collagen, Type I from calf skin

Synonyms Collagensoluble; Collagen type I

CAS Number: 9007-34-5

EC Number: 232-697-4 MDL Number: MFCD00130825

SKU 02160084-CF
$95.30
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Description

Product Description

Collagen

Application Notes

Collagen Type I has been used as a scaffold for the growth of stem cells in vitro, in a wide variety of biomaterial engineering studies. Collagen type I may be used in research of Idiopathic pulmonary fibrosis (IPF). Robust expression of collagen-type 1 is one distinctive feature of IPF. Additionally, collagen-type I has been used in studies on the effect of endoplasmic reticulum (ER) stress from IPF on myofibroblastic differentiation of lung fibroblasts. Collagen-type 1 soluble in acidic solution produces three dimensional scaffolding useful in bioengineering and cell culture applications where biomaterials are needed to replace native collagen extracellular matrices.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Bioengineering

Specifications
SKU 02160084-CF
Alternate Names Collagensoluble; Collagen type I
Application Notes Collagen Type I has been used as a scaffold for the growth of stem cells in vitro, in a wide variety of biomaterial engineering studies. Collagen type I may be used in research of Idiopathic pulmonary fibrosis (IPF). Robust expression of collagen-type 1 is one distinctive feature of IPF. Additionally, collagen-type I has been used in studies on the effect of endoplasmic reticulum (ER) stress from IPF on myofibroblastic differentiation of lung fibroblasts. Collagen-type 1 soluble in acidic solution produces three dimensional scaffolding useful in bioengineering and cell culture applications where biomaterials are needed to replace native collagen extracellular matrices.
Base Catalog Number 160084
CAS # 9007-34-5
EC Number 232-697-4
Format lyophilized, Salt-free, Soluble
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Preparation Method It is prepared according to the method of Gallop and Seifter. In the method, fresh calf skin is extracted with 0.5 M NaOAc to remove non-collagen proteins. The soluble collagen is extracted with 0.075 M Sodium citrate, pH 3.7, and precipitated as fibrils by dialysis against 0.02 M Na2HPO4.It is prepared according to the method of Gallop and Seifter. In the method, fresh calf skin is extracted with 0.5 M NaOAc to remove non-collagen proteins. The soluble collagen is extracted with 0.075 M Sodium citrate, pH 3.7, and precipitated as fibrils by dialysis against 0.02 M Na2HPO4.
Source Calf skin
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.