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Chloramphenicol, phytopure™

Chloramphenicol, phytopure™

Synonyms D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin; Anacetin; Chlomin; Embacetin; Mychel; veticol

CAS Number: 56-75-7 Molecular Formula: C11H12Cl2N2O5 Molecular Weight: 323.20

Beilstein Registry Number: 2225532 EC Number: 200-287-4 MDL Number: MFCD00078159

SKU 02190321-CF
$35.30
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Description

Product Description

A synthetic antibiotic first isolated from Streptomyces venezuelae. It is effective against gram-positive and gram-negative bacteria. It interferes with translation on the 50S ribosomal subunit at the peptidyl transferase step (elongation inhibition) and inhibits mitochondrial and chloroplast protein synthesis.

Application Notes

Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic (eye drops) and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Specifications
SKU 02190321-CF
Alternate Names D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin; Anacetin; Chlomin; Embacetin; Mychel; veticol
Application Notes Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic (eye drops) and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Base Catalog Number 190321
Beilstein Registry Number 2225532
Biochemical Physiological Actions Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Boiling Point Sublimes
CAS # 56-75-7
EC Number 200-287-4
Extinction Coefficient (278 nm) = 298 (water) (Lit.)
Format Powder
Hazard Statements H350
Melting Point 171
Molecular Formula C11H12Cl2N2O5
Molecular Weight 323.20
Optical Rotation (c=5 ethanol)+18 ° ± 5 °
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
pH NEUTRAL TO LITMUS
Purity >99%
RTECS Number AB6825000
Safety Symbol GHS08
Solubility Water Solubility2500 mg/L (at 25 °C)
Typical Working Concentration 5 -20 µg/mL
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 1.7X10-12 mm Hg at 25 deg C /Estimated/