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Cephalexin monohydrate, USP grade, ≥95%

Cephalexin monohydrate, USP grade, ≥95%

$118.90
Cephalexin Monohydrate

SKU: 02150585-CF

Synonyms
7-(d-a-Aminophenylacetamido)desacetoxycephalosporanic acid; Cefalexin monohydrate; [6R-[6α,7β(R*)]]-7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid monohydrate; 7-(Dα-aminophenylacetamido) desacetoxycephalosporanic acid monohydrate
CAS Number:
23325-78-2
Molecular Formula:
C16H17N3O4S·H2O
Molecular Weight:
365.404 g/mol
Beilstein Registry Number:
965503
EC Number:
239-773-6
MDL Number:
MFCD00167148
Product Description

Cephalexin Monohydrate

Application Notes

Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Cephalexin and other antibiotics have been shown to inhibit p-aminohippurate uptake by the rat renal organic anion transporter 1, as expressed in Xenopus laevis oocytes. A study of CHO cells transfected with the vector for the H+-coupled peptide transporter PEPT1 has shown that cephalexin is a competitor for dipeptide transport. Cephalexin has been used to culture E. coli at 10 µg/mL for the expression of fusion proteins.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibacterial | Antibiotics

Specifications
SKU 02150585-CF
Alternate Names 7-(d-a-Aminophenylacetamido)desacetoxycephalosporanic acid; Cefalexin monohydrate; [6R-[6α,7β(R*)]]-7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid monohydrate; 7-(Dα-aminophenylacetamido) desacetoxycephalosporanic acid monohydrate
Application Notes Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Cephalexin and other antibiotics have been shown to inhibit p-aminohippurate uptake by the rat renal organic anion transporter 1, as expressed in Xenopus laevis oocytes. A study of CHO cells transfected with the vector for the H+-coupled peptide transporter PEPT1 has shown that cephalexin is a competitor for dipeptide transport. Cephalexin has been used to culture E. coli at 10 µg/mL for the expression of fusion proteins.
Base Catalog Number 150585
Beilstein Registry Number 965503
Biochemical Physiological Actions Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.
CAS # 23325-78-2
EC Number 239-773-6
Extinction Coefficient 7.75(Lit.)
Format Powder
Grade USP
Hazard Statements H317-H334
Melting Point 326.8 °C
Molecular Formula C16H17N3O4S·H2O
Molecular Weight 365.404 g/mol
Optical Rotation +149° to +158° (pH 4.4)
Personal Protective Equipment Dust mask , Eyeshields, Faceshields, Gloves
pKa 5.2, 7.3(Lit.)
Potency 950 - 1010 µg/mg (anhydrous basis)
Purity ≥95%
RTECS Number XI0350000
Safety Symbol GHS08
Solubility Water Solubility1.789 mg/mL as monohydrate salt (solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance 260 - 262 nm (water)
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