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Actinomycin D, cell culture reagent

Actinomycin D, cell culture reagent

Actinomycin D

SKU: 02194525-CF

Synonyms
Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen
CAS Number:
50-76-0
Molecular Formula:
C62H86N12O16
Molecular Weight:
1255.438 g/mol
EC Number:
200-063-6
MDL Number:
MFCD00005033
Product Description

Actinomycin D

Application Notes

Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic

Specifications
SKU 02194525-CF
Alternate Names Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen
Application Notes Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.
Base Catalog Number 194525
Biochemical Physiological Actions Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
CAS # 50-76-0
EC Number 200-063-6
Format Crystalline
Grade Cell Culture Grade
Hazard Statements H300
Melting Point 467 to 469° F (decomposes) (NTP, 1992)
Molecular Formula C62H86N12O16
Molecular Weight 1255.438 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge
Purity ~98%
Refractive Index 1.656(lit.)
RTECS Number AU1575000
Safety Symbol GHS06
Solubility Soluble at 50° F (NTP, 1992)
Typical Working Concentration cell culture applications at 1µg/mL.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 0 mm Hg at 25 deg C (est)
Documents

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