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Actinomycin D, ~98%, 5 mg

Actinomycin D, ~98%, 5 mg

Synonyms Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen

CAS Number: 50-76-0 Molecular Formula: C62H86N12O16 Molecular Weight: 1255.5

Beilstein Registry Number: 605235 EC Number: 200-063-6 MDL Number: MFCD00005033

Packaging size: 5 mg

SKU 0219603505
$93.75
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Description

Product Description

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.

Application Notes

Actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Actinomycin induces apoptosis and is used as a potent antitumor agent. It is a nucleic acid synthesis inhibitor. It is sed for its antineoplastic properties in the treatment of various malignant neoplasms including Wilm’s tumour, and the sarcomas.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Selection agent | potent antitumor agent | nucleic acid synthesis inhibitor

Specifications
SKU 0219603505
Alternate Names Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen
Application Notes Actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Actinomycin induces apoptosis and is used as a potent antitumor agent. It is a nucleic acid synthesis inhibitor. It is sed for its antineoplastic properties in the treatment of various malignant neoplasms including Wilm’s tumour, and the sarcomas.
Base Catalog Number 19603505
Beilstein Registry Number 605235
Biochemical Physiological Actions An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
CAS # 50-76-0
EC Number 200-063-6
Extinction Coefficient E1% (244nm) = 281 (methanol), E1% (441nm) = 206 (methanol) , EmM (240 nm) = 34.1 (methanol) , EmM (443 nm) = 24.4 (methanol)(Lit.)
Hazard Statements H300
Melting Point 251-253 °C(Lit.)
Molecular Formula C62H86N12O16
Molecular Weight 1255.5
Optical Rotation [α]28D : −315° (c = 0.25% in methanol)(Lit.)
Pack Size 5 mg
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Purity 98%
RTECS Number AU1575000
Safety Symbol GHS06
Solubility Soluble in methanol (10 mg/mL - clear, orange solution), soluble in DMSO (50 mg/ mL-clear, orange solution), ethanol, chloroform, benzene, ethyl acetate, propylene glycol, chloroform, acetone, water + glycol mixtures.
Typical Working Concentration 1 ug/mL
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.