13-cis-Retinoic acid

Name: 13-cis-Retinoic acid
SKU: 02156518-CF
Price: 87.39 USD

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SKU: 02156518-CF

Key features and details

13-Cis-Retinoic Acid

Synonyms

Isotretinoin

CAS Number:

4759-48-2

Molecular Formula:

C20H28O2

Molecular Weight:

300.442 g/mol

EC Number:

225-296-0

MDL Number:

MFCD00079542

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Product Description

13-Cis-Retinoic Acid

Application Notes

13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Anti-inflammatory | Anti-tumor

Specifications

SKU	02156518-CF
Alternate Names	Isotretinoin
Application Notes	13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.
Base Catalog Number	156518
Biochemical Physiological Actions	The action of 13-cis-Retinoic acid (RA) is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.
CAS #	4759-48-2
EC Number	225-296-0
Format	Powder
Hazard Statements	H315-H319-H335-H360
Melting Point	372 to 374Â° F (NTP, 1992)
Molecular Formula	C20H28O2
Molecular Weight	300.442 g/mol
Personal Protective Equipment	Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS Number	VH6440000
Safety Symbol	GHS07, GHS08
Solubility	less than 1 mg/mL at 72Â° F (NTP, 1992)
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance	λ max (ethanol): 354 ± 3 nm
Vapor Pressure	1.0X10-7 mm Hg @ 25 deg C /Estimated/