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13-cis-Retinoic acid

13-cis-Retinoic acid

Synonyms Isotretinoin

CAS Number: 4759-48-2 Molecular Formula: C20H28O2 Molecular Weight: 300.442 g/mol

EC Number: 225-296-0 MDL Number: MFCD00079542

SKU 02156518-CF
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Description

Product Description

13-Cis-Retinoic Acid

Application Notes

13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Anti-inflammatory | Anti-tumor

Specifications
SKU 02156518-CF
Alternate Names Isotretinoin
Application Notes 13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.
Base Catalog Number 156518
Biochemical Physiological Actions The action of 13-cis-Retinoic acid (RA) is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.
CAS # 4759-48-2
EC Number 225-296-0
Format Powder
Hazard Statements H315-H319-H335-H360
Melting Point 372 to 374° F (NTP, 1992)
Molecular Formula C20H28O2
Molecular Weight 300.442 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS Number VH6440000
Safety Symbol GHS07, GHS08
Solubility less than 1 mg/mL at 72° F (NTP, 1992)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λ max (ethanol): 354 ± 3 nm
Vapor Pressure 1.0X10-7 mm Hg @ 25 deg C /Estimated/