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Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine through the addition of aminopropyl group to spermidine by spermine synthase. It is found as a polycation at physiological pH.
DNA precipitation | Chromosome isolation | Crystallization of DNA
|Alternate Names||Diaminopropyltetramethylenediamine; Gerontine; Musculamine; Neuridine; N,N-bis(aminopropyl)-1,4-butanediamine; 4,9-Diaza-1,12-dodecanediamine|
|Base Catalog Number||152070|
|Beilstein Registry Number||1750791|
|Biochemical Physiological Actions||Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).|
|Boiling Point||141-142°C at 0.5 mm Hg;|
|Flash Point||110 °C / 230 °F (lit.)|
|Melting Point||28-30°C (Lit.)|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator ,Gloves, respirator cartridge, respirator filter|
|pH||11-14 (0.5% aq soln)|
|Solubility||Soluble in water (1% w/v), lower alcohol, chloroform; practically insoluble in ether, benzene, petroleum ether.|