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2-Iminothiolane hydrochloride

2-Iminothiolane hydrochloride

Synonyms 2-Thiolanimine hydrochloride; 2IT; Dihydro-2(3H)-thiophenimine hydrochloride; Trauts reagent

CAS Number: 4781-83-3 Molecular Formula: C4H7NS·HCl Molecular Weight: 137.625 g/mol

Beilstein Registry Number: 3620079 MDL Number: MFCD00039013

SKU 02151319-CF
$50.25
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Description

Product Description

2-Iminothiolane Hydrochloride

Application Notes

2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking. It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Protein modification and cross-linking reagent

Specifications
SKU 02151319-CF
Alternate Names 2-Thiolanimine hydrochloride; 2IT; Dihydro-2(3H)-thiophenimine hydrochloride; Trauts reagent
Application Notes 2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking. It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.
Base Catalog Number 151319
Beilstein Registry Number 3620079
CAS # 4781-83-3
Extinction Coefficient EmM = 8.84 (0.1 M HCl)(Lit.)
Format Powder
Molecular Formula C4H7NS·HCl
Molecular Weight 137.625 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Source Synthetic
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λ max: 248 nm (Lit.)