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Iodoacetamide

Iodoacetamide

Synonyms IAN; alpha-Iodoacetamide; Monoiodoacetamide; 2-Iodoacetamide; Surauto

CAS Number: 144-48-9 Molecular Formula: C2H4INO Molecular Weight: 184.964 g/mol

Beilstein Registry Number: 1739080 EC Number: 205-630-1 MDL Number: MFCD00008028

SKU 02100351-CF
$45.80
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Description

Product Description

Iodoacetamide

Application Notes

Iodoacetamide is useful in peptide sequencing and as an irreversible enzyme inhibitor. Some enzymes iodoacetamide will inhibit include (but is not limited to): Alcohol dehydrogenase, Alkaline phosphatase (calf intestinal), beta-Amylase, Cathepsin B, Galactose oxidase, Heme oxygenase, L-Lysine decarboxylase. It will irreversibly inhibit the dephosphorylation of both epidermal growth factor receptor and platelet-derived growth factor receptor by alkylation at the active center of one or several protein tyrosine phosphatases in cell lines. Iodoacetamide will also irreversibly inhibit many cysteine proteases. Alkylating reagent for cysteine residues in peptide sequencing. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Enzymes | Inhibitors | Substrates

Specifications
SKU 02100351-CF
Alternate Names IAN; alpha-Iodoacetamide; Monoiodoacetamide; 2-Iodoacetamide; Surauto
Application Notes Iodoacetamide is useful in peptide sequencing and as an irreversible enzyme inhibitor. Some enzymes iodoacetamide will inhibit include (but is not limited to): Alcohol dehydrogenase, Alkaline phosphatase (calf intestinal), beta-Amylase, Cathepsin B, Galactose oxidase, Heme oxygenase, L-Lysine decarboxylase. It will irreversibly inhibit the dephosphorylation of both epidermal growth factor receptor and platelet-derived growth factor receptor by alkylation at the active center of one or several protein tyrosine phosphatases in cell lines. Iodoacetamide will also irreversibly inhibit many cysteine proteases. Alkylating reagent for cysteine residues in peptide sequencing. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.
Base Catalog Number 100351
Beilstein Registry Number 1739080
CAS # 144-48-9
EC Number 205-630-1
Format Powder
Hazard Statements H301-H317-H334-H413
Molecular Formula C2H4INO
Molecular Weight 184.964 g/mol
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator cartridges
RTECS Number AC4200000
Safety Symbol GHS06, GHS08
Typical Working Concentration The effective concentration for use as a protease inhibitor is 10-100 uM.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance 267 ± 2 nm (water)