3-Isobutyl-1-Methyl Xanthine

3-Isobutyl-1-Methyl Xanthine

Synonyms IBMX; MIX; MeiBu-Xan; IBX; 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione

CAS Number: 28822-58-4 Molecular Formula: C10H14N4O2 Molecular Weight: 222.25

Beilstein Registry Number: 247859 EC Number: 249-259-3 MDL Number: MFCD00005584

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SKU 02195262-CF
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Description

Product Description

IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.

Application Notes

IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Inhibition | Cell Signalling

Specifications
SKU 02195262-CF
Alternate Names IBMX; MIX; MeiBu-Xan; IBX; 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
Application Notes IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
Beilstein Registry Number 247859
Biochemical Physiological Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 µM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.
EC Number 249-259-3
Applications Inhibition | Cell Signalling
MDL # MFCD00005584
Melting Point 195 - 202 °C
Molecular Formula C10H14N4O2
Molecular Weight 222.25
Personal Protective Equipment Dust mask , Eyeshields, Faceshields, Gloves
Physical Appearance White Powder
RTECS Number ZD8500000
Safety Symbol GHS07
Solubility Soluble in Krebs-Henseleit bicarbonate buffer, ethanol (10 mg/mL or 25 mg/mL with sonication), DMSO (1 M with warming), or aqueous NaOH (pH 9.5); slightly soluble in water (0.3 mg/mL hot water). Solubility in 45% (w/v) aqueous 2-hydroxy-propyl-b-cyclodextrin is 3.2 mg/mL.
Storage and Handling Store at -0 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.