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Lithium Chloride

Lithium Chloride

Synonyms Chlorku litu; Chlorure de lithium; Lithiumchlorid

CAS Number: 7447-41-8 Molecular Formula: LiCl Molecular Weight: 42.39 g/mol

EC Number: 231-212-3 MDL Number: MFCD00011078

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SKU 02194010-CF
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Description

Product Description

Lithium Chloride

Application Notes

Lithium Chloride is used as an electrolyte for low temperature dry battery cells and as an oxidation catalyst. It is a solubilizer for polyamides and cellulose when used with amide solvents, and is a chlorinating agent for steroid substrates. It has also been utilized in: Large scale plasmid DNA isolation without ultracentrifugation; Protein extraction and protein crystallization; Crystallization of other biological structures, including vitamin B12-RNA aptamer and the L-A virus particle; Inhibits the expression and secretion of insulin-like growth factor-binding protein-1 in H4-II-E cells; Used in the synthesis of beta-substituted alpha-amino acid derivatives; May be used to selectively pre­cipitate RNA.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Chemical Synthesis||DNA & RNA Purification||Protein extraction||Protein crystallization

Specifications
SKU 02194010-CF
Application Notes Lithium Chloride is used as an electrolyte for low temperature dry battery cells and as an oxidation catalyst. It is a solubilizer for polyamides and cellulose when used with amide solvents, and is a chlorinating agent for steroid substrates. It has also been utilized in: Large scale plasmid DNA isolation without ultracentrifugation; Protein extraction and protein crystallization; Crystallization of other biological structures, including vitamin B12-RNA aptamer and the L-A virus particle; Inhibits the expression and secretion of insulin-like growth factor-binding protein-1 in H4-II-E cells; Used in the synthesis of beta-substituted alpha-amino acid derivatives; May be used to selectively pre­cipitate RNA.
Biochemical Physiological Actions In developing Xenopus embryos, Lithium Chloride is observed to exert inhibition of glycogen synthase kinase-3β (GSK-3β), yet not reported to be a general inhibitor of other protein kinases. These observations may have implications for Lithium Chloride on cell-fate determination in several organisms including Xenopus and Dictyostelium. Additionally, in transfected Chinese Hamster Ovary cells (CHO) stimulated with angiotension II (Ang II), it was noted that Lithium Chloride enhanced the production of inositol triphosphate. Lithium Chloride may also have anti-viral properties as reported by a study that noted that the compund inhibited pseudorabis virus infection in vitro. In Drosophila, it was observed that in the nervous system, Lithium Chloride may have an effect on amino acid metabolism. Futhermore, in glial primary cell cultures, Lithium Chloride has been noted to provide protection against glutamate excitotoxicity by potentially reducing NR1 mRNA, the major N-methyl-D-aspartate receptor (NMDAR) subunit in the cells.
Boiling Point 2417 to 2480° F at 760 mm Hg (NTP, 1992)
Density 2.068 at 77° F (NTP, 1992)
EC Number 231-212-3
Format powder
Grade Molecular biology reagent
Hazard Statements H302-H315-H319-H335
Applications Chemical Synthesis||DNA & RNA Purification||Protein extraction||Protein crystallization
Melting Point 1121° F (NTP, 1992)
Molecular Formula LiCl
Molecular Weight 42.39 g/mol
Partition Coefficient Log P(oct) = -2.66(Lit.)
Personal Protective Equipment Dust mask , Eyeshields, Gloves
pH Aqueous solution: neutral or slightly alkaline
Physical Appearance White Crystalline Powder
Product Families Description Lithium chloride
Product Overview Lithium Chloride
Purity >99%
RTECS Number OJ5950000
Safety Symbol GHS07
Solubility Very soluble (NTP, 1992)
Storage and Handling Store at Room Temperature (15-30 °C);desiccate.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 1 mm Hg at 547 deg C