Spermine Un3259-Iii (8)
Product Description
Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine through the addition of aminopropyl group to spermidine by spermine synthase. It is found as a polycation at physiological pH.
Usage Statement
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Key Applications
DNA precipitation | Chromosome isolation | Crystallization of DNA
SKU | 02152070-CF |
Beilstein Registry Number | 1750791 |
Biochemical Physiological Actions | Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
Boiling Point | 141-142°C at 0.5 mm Hg; |
EC Number | 200-754-2 |
Flash Point | 110 °C / 230 °F (lit.) |
Hazard Statements | H314 |
Applications | DNA precipitation | Chromosome isolation | Crystallization of DNA |
Melting Point | 28-30°C (Lit.) |
Molecular Formula | C10H26N4 |
Molecular Weight | 202.3 |
Pack Size | No |
Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator ,Gloves, respirator cartridge, respirator filter |
pH | 11-14 (0.5% aq soln) |
Physical Appearance | Colorless Solid |
Purity | ≥97% |
RTECS Number | EJ7175000 |
Safety Symbol | GHS05 |
Solubility | Soluble in water (1% w/v), lower alcohol, chloroform; practically insoluble in ether, benzene, petroleum ether. |
Storage and Handling | +4°C; desiccate; store under nitrogen |
Usage Statement | Research Use Only (RUO). Ready for CE IVD labeling of clinical applications. |