Spermine Un3259-Iii (8)
Description
Product Description
Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine through the addition of aminopropyl group to spermidine by spermine synthase. It is found as a polycation at physiological pH.
Usage Statement
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Key Applications
DNA precipitation | Chromosome isolation | Crystallization of DNA
Specifications
| SKU | 02152070-CF |
| Alternate Names | Diaminopropyltetramethylenediamine; Gerontine; Musculamine; Neuridine; N,N-bis(aminopropyl)-1,4-butanediamine; 4,9-Diaza-1,12-dodecanediamine |
| Beilstein Registry Number | 1750791 |
| Biochemical Physiological Actions | Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
| Boiling Point | 141-142°C at 0.5 mm Hg; |
| EC Number | 200-754-2 |
| Flash Point | 110 °C / 230 °F (lit.) |
| Hazard Statements | H314 |
| Applications | DNA precipitation | Chromosome isolation | Crystallization of DNA |
| MDL # | MFCD00008215 |
| Melting Point | 28-30°C (Lit.) |
| Molecular Formula | C10H26N4 |
| Molecular Weight | 202.3 |
| Pack Size | No |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator ,Gloves, respirator cartridge, respirator filter |
| pH | 11-14 (0.5% aq soln) |
| Physical Appearance | Colorless Solid |
| Purity | ≥97% |
| RTECS Number | EJ7175000 |
| Safety Symbol | GHS05 |
| Solubility | Soluble in water (1% w/v), lower alcohol, chloroform; practically insoluble in ether, benzene, petroleum ether. |
| Storage and Handling | +4°C; desiccate; store under nitrogen |
| Usage Statement | Research Use Only (RUO). Ready for CE IVD labeling of clinical applications. |