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2-Iminothiolane Hydrochloride

2-Iminothiolane Hydrochloride

Synonyms 2-Thiolanimine hydrochloride; 2IT; Dihydro-2(3H)-thiophenimine hydrochloride; Trauts reagent

CAS Number: 4781-83-3 Molecular Formula: C4H7NS·HCl Molecular Weight: 137.625 g/mol

Beilstein Registry Number: 3620079 MDL Number: MFCD00039013

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SKU 02151319-CF
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Description

Product Description

2-Iminothiolane Hydrochloride

Application Notes

2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking. It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Protein modification and cross-linking reagent

Specifications
SKU 02151319-CF
Application Notes 2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking. It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.
Beilstein Registry Number 3620079
Extinction Coefficient EmM = 8.84 (0.1 M HCl)(Lit.)
Format powder
Applications Protein modification and cross-linking reagent
Molecular Formula C4H7NS·HCl
Molecular Weight 137.625 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance Powder
Product Families Description 2-Iminothiolane hydrochloride
Product Overview 2-Iminothiolane Hydrochloride
Source Synthetic
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance λ max: 248 nm (Lit.)