Orotic Acid Monohydrate

Orotic Acid Monohydrate

Synonyms 2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid; Uracil-6-carboxylic acid; Whey factor; Animal galactose factor; Oropur; Orotyl; 6-Carboxy-2,4-dihydroxypyrimidine

CAS Number: 50887-69-9 Molecular Formula: C5H4N2O4 • H2O Molecular Weight: 174.112 g/mol

Beilstein Registry Number: 7604036 MDL Number: MFCD00149398

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SKU 02102508-CF
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Description

Product Description

Orotic Acid Monohydrate

Application Notes

Orotic acid (OA) may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Used in study of biosynthesis of pyrimidine nucleobases

Specifications
SKU 02102508-CF
Alternate Names 2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid; Uracil-6-carboxylic acid; Whey factor; Animal galactose factor; Oropur; Orotyl; 6-Carboxy-2,4-dihydroxypyrimidine
Application Notes Orotic acid (OA) may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.
Beilstein Registry Number 7604036
Format powder
Hazard Statements H315-H319-H335
Applications Used in study of biosynthesis of pyrimidine nucleobases
Loss on Drying ~10%
MDL # MFCD00149398
Molecular Formula C5H4N2O4 • H2O
Molecular Weight 174.112 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance White Powder
Product Families Description Orotic acid monohydrate
Product Overview Orotic Acid Monohydrate
Safety Symbol GHS07
Storage and Handling Room Temperature
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance λ max (water) 205 nm (280 nm) ± 5 nm