Spermine Tetrahydrochloride

Spermine Tetrahydrochloride

Synonyms N,N-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Geontine Tetrahydrochloride

CAS Number: 306-67-2 Molecular Formula: C10H26N4 · 4HCl Molecular Weight: 348.2

Beilstein Registry Number: 3911771 EC Number: 206-189-8 MDL Number: MFCD00012914

Configure Your Product:

SKU 02100474-CF
Price:
$54.10
In Stock
Request a quote
Description

Product Description

Spermine is a naturally occuring polyamine that occurs in all eukaryotes, but is rare in prokaryotes. It is essential for cell growth in both normal and neoplastic tissue. Spermine is formed through the addition of a aminopropyl group to spermidine by spermine synthase. Spermine is strongly basic in character, and in aqueous solution at physiological pH, all of its amino groups will be positively charged.

Application Notes

Used to precipitate DNA from low salt aqueous buffers. Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Isolation of DNA | Precipitation of DNA

Specifications
SKU 02100474-CF
Alternate Names N,N-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Geontine Tetrahydrochloride
Application Notes Used to precipitate DNA from low salt aqueous buffers. Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.
Beilstein Registry Number 3911771
Biochemical Physiological Actions Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site.
Chemical Class Biochemicals
EC Number 206-189-8
Hazard Statements H315-H319
Applications Isolation of DNA | Precipitation of DNA
MDL # MFCD00012914
Melting Point 312-314 °C (Lit.)
Molecular Formula C10H26N4 · 4HCl
Molecular Weight 348.2
Pack Size No
Personal Protective Equipment Dust Mask, Eyeshields, Gloves.
pH 6.6 (1M)
Physical Appearance White Powder
Purity ≥96%
RTECS Number EJ7230000
Safety Symbol GHS07
Solubility Soluble in water (100 mg/mL - clear, colorless solution).
Storage and Handling -20°C; desiccate
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.