Iodoacetamide

Iodoacetamide

Synonyms IAN; alpha-Iodoacetamide; Monoiodoacetamide; 2-Iodoacetamide; Surauto

CAS Number: 144-48-9 Molecular Formula: C2H4INO Molecular Weight: 184.964 g/mol

Beilstein Registry Number: 1739080 EC Number: 205-630-1 MDL Number: MFCD00008028

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SKU 02100351-CF
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Description

Product Description

Iodoacetamide

Application Notes

Iodoacetamide is useful in peptide sequencing and as an irreversible enzyme inhibitor. Some enzymes iodoacetamide will inhibit include (but is not limited to): Alcohol dehydrogenase, Alkaline phosphatase (calf intestinal), beta-Amylase, Cathepsin B, Galactose oxidase, Heme oxygenase, L-Lysine decarboxylase. It will irreversibly inhibit the dephosphorylation of both epidermal growth factor receptor and platelet-derived growth factor receptor by alkylation at the active center of one or several protein tyrosine phosphatases in cell lines. Iodoacetamide will also irreversibly inhibit many cysteine proteases. Alkylating reagent for cysteine residues in peptide sequencing. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Enzymes||Inhibitors||Substrates

Specifications
SKU 02100351-CF
Alternate Names IAN; alpha-Iodoacetamide; Monoiodoacetamide; 2-Iodoacetamide; Surauto
Application Notes Iodoacetamide is useful in peptide sequencing and as an irreversible enzyme inhibitor. Some enzymes iodoacetamide will inhibit include (but is not limited to): Alcohol dehydrogenase, Alkaline phosphatase (calf intestinal), beta-Amylase, Cathepsin B, Galactose oxidase, Heme oxygenase, L-Lysine decarboxylase. It will irreversibly inhibit the dephosphorylation of both epidermal growth factor receptor and platelet-derived growth factor receptor by alkylation at the active center of one or several protein tyrosine phosphatases in cell lines. Iodoacetamide will also irreversibly inhibit many cysteine proteases. Alkylating reagent for cysteine residues in peptide sequencing. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.
Beilstein Registry Number 1739080
EC Number 205-630-1
Format powder
Hazard Statements H301-H317-H334-H413
Applications Enzymes||Inhibitors||Substrates
MDL # MFCD00008028
Molecular Formula C2H4INO
Molecular Weight 184.964 g/mol
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator cartridges
Physical Appearance Tan Powder
Product Families Description Iodoacetamide
Product Overview Iodoacetamide
RTECS Number AC4200000
Safety Symbol GHS06, GHS08
Storage and Handling Store at -0 °C; protect from light.
Typical Working Concentration The effective concentration for use as a protease inhibitor is 10-100 uM.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance 267 ± 2 nm (water)