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Specifications
| SKU | 0215693401 |
| Alternate Names | Methyl-[3-methylphenyl]-carbamothioic acid O-2-naphthyl ester; Carbamothioic acid |
| Application Notes | Tolfanate is an antifungal compound which has activity against such species as Epidermophyton, Microsporum, Trichophyton species, and Malassezia furfur. It is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies. |
| Base Catalog Number | 15693401 |
| Biochemical Physiological Actions | Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin. |
| CAS # | 2398-96-1 |
| EC Number | 219-266-6 |
| Extinction Coefficient | E1% = 690 -740 at λ max 257 - 258 NM in methanol (Lit.) |
| Melting Point | 108 - 115 °C |
| Molecular Formula | C19H17NOS |
| Molecular Weight | 307.42 |
| Pack Size | 1 g |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| RTECS Number | FD8891300 |
| Solubility | Soluble in chloroform (50 mg/mL - clear, colorless to faint yellow solution). Insoluble in cold and hot water. It is also soluble in acetone and sparingly soluble in ethanol and methanol. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Documents
Certificate of Analysis (COA)
![MP COA [156934] lot ID: SR04218](https://www.mpbio.com/static/version1787211969/frontend/Mpbio/luma/en_US/images/document.png "MP COA [156934] lot ID: SR04218")
Datasheet
Datasheet
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