Spectinomycin Dihydrochloride Pentahydrate
Application Notes
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Treatment of gonorrhea | Selection agent for transformed plant cells
| SKU | 0215206705 |
| Alternate Names | U18409AE; Actinospectacin; M141 |
| Application Notes | Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. |
| Base Catalog Number | 15206705 |
| Biochemical Physiological Actions | Mode of Action: Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (Gonnococcus only). Mode of Resistance: Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin. |
| CAS # | 22189-32-8 |
| EC Number | 244-554-3 |
| Format | Powder |
| Molecular Formula | C14H24N2O7 • 2HCl • 5H2O |
| Molecular Weight | 495.344 g/mol |
| Optical Rotation | Positive |
| Pack Size | 5 g |
| Personal Protective Equipment | Eyeshields, Gloves, respirator cartridges |
| Potency | ≥500 µg/mg |
| RTECS Number | WG7400000 |
| Source | Streptomyces sp. |
| Typical Working Concentration | recommended for use in cell culture applications at 7.5-20 mg/L |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![MP COA [152067] lot ID: M4520](https://www.mpbio.com/static/version1741337905/frontend/Mpbio/default/en_US/images/document.png "MP COA [152067] lot ID: M4520")