(6R)-5,6,7,8-Tetrahydro-l-biopterin dihydrochloride

Product Description

(6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride

Application Notes

(6R)-5,6,7,8-Tetrahydro-L-biopterin Dihydrochloride is necessary in vivo for the conversion of phenylalanine to tyrosine and for the production of the hormone epinephrine and of the monoamine neurotransmitters, serotonin, dopamine, and norepinephrine. It is also involved in apoptosis and other cellular events mediated by nitric oxide production and catalyzes the cleavage of alkylglycerol ethers. (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Cofactor

Specifications

SKU	02153622-CF
Alternate Names	(6R)-BH4-Amino-6-(1,2-dihydroxy-propyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride; BH4; (6R)-BH4; (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; Sapropterin; Dapropterin
Application Notes	(6R)-5,6,7,8-Tetrahydro-L-biopterin Dihydrochloride is necessary in vivo for the conversion of phenylalanine to tyrosine and for the production of the hormone epinephrine and of the monoamine neurotransmitters, serotonin, dopamine, and norepinephrine. It is also involved in apoptosis and other cellular events mediated by nitric oxide production and catalyzes the cleavage of alkylglycerol ethers. (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues.
Base Catalog Number	153622
Biochemical Physiological Actions	Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase.
CAS #	69056-38-8
Extinction Coefficient	EM(216 nm)=15,400 (0.1 N HCl); (264 nm) = 13,750 (0.1 N HCl)(Lit.)
Format	Powder
Hazard Statements	H302
Melting Point	250 - 255 Â°C (hydrochloride salt)
Molecular Formula	C9H15N5O3·2HCl
Molecular Weight	241.251 g/mol
Optical Rotation	[α]D = -6.6° to –7.6° (C = 1 in 0.1 N HCl)(Lit.)
RTECS Number	UO3516000
Safety Symbol	GHS07
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.