NZ Bovine Thrombin, Low Specific Activity

Name: NZ Bovine Thrombin, Low Specific Activity
SKU: 02199907-CF
Price: 145 CHF

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SKU: 02199907-CF

Key features and details

Manufactured in a state-of-the-art facility in New Zealand using a chromatographic extraction process, under Quality Systems that are ISO Certified

Synonyms

Factor IIa; Thrombin from bovine plasma

CAS Number:

9002-04-4

EC Number:

232-648-7

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Product Description

Thrombin is used throughout the diagnostics industry in a variety of coagulation assays, clotting factor tests and defibrination of blood or plasma for serum controls. Thrombin is also used for site specific cleavage of recombinant fusion proteins and in biochemical and medical research applications.
Bovine thrombin, low specific activity, is manufactured in New Zealand from bovine plasma of New Zealand origin using prothrombin activated with thromboplastin extracted from bovine lung tissue. Low specific activity Thrombin is lyophilized under vacuum in glass vials, or in closed trays as a bulk powder, depending on customer requirements. Low specific activity thrombin has a specific activity of 90-300 NIH units/mg protein and greater than 50% total protein.

Application Notes

Thrombin is used throughout the diagnostics industry in a variety of coagulation assays, clotting factor tests and defibrination of blood or plasma for serum controls. Thrombin is also used for site specific cleavage of recombinant fusion proteins, and in biochemical and medical research applications. Bovine Thrombin, low specific activity, is manufactured from New Zealand-sourced bovine plasma using prothrombin activated with thromboplastin extracted from bovine lung tissue. Thrombin is lyophilized in glass vials under vacuum to optimize product performance. Low specific activity thrombin has 90 - 300 NIH units/mg and greater than 50% total protein. Thrombin has been used in a study to assess persistent hypocoagulability in patients with septic shock.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Specifications

SKU	02199907-CF
Alternate Names	Factor IIa; Thrombin from bovine plasma
Application Notes	Thrombin is used throughout the diagnostics industry in a variety of coagulation assays, clotting factor tests and defibrination of blood or plasma for serum controls. Thrombin is also used for site specific cleavage of recombinant fusion proteins, and in biochemical and medical research applications. Bovine Thrombin, low specific activity, is manufactured from New Zealand-sourced bovine plasma using prothrombin activated with thromboplastin extracted from bovine lung tissue. Thrombin is lyophilized in glass vials under vacuum to optimize product performance. Low specific activity thrombin has 90 - 300 NIH units/mg and greater than 50% total protein. Thrombin has been used in a study to assess persistent hypocoagulability in patients with septic shock.
Base Catalog Number	199907
Biochemical Physiological Actions	Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.
CAS #	9002-04-4
EC Number	232-648-7
Extinction Coefficient	E<sub>280</sub><sup>1%</sup> = 18.3 (human); E<sub>280</sub><sup>1%</sup> = 19.5 (bovine)
Format	Lyophilized powder
Grade	Analytical Grade
Hazard Statements	H315-H319-H334-H335
Host	Bovine
pH	7.0 - 8.0
Protein or Enzyme Type	Plasma & Blood Proteins
RTECS Number	XO8950000
Safety Symbol	GHS07, GHS08
Specific Activity	90 - 300 u/mg protein
Unit Definition	Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard, Lot K. The NIH assay procedure uses 0.2 mL of diluted plasma (1:1 with saline) as a substrate and 0.1 mL of albumin solution based on a modification of the method of Biggs. Only clotting times in the range of 15–25 seconds are used for determining thrombin activity. Optimal clotting temperature is 37 °C.
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.