Lysing Matrix Tubes
Get reproducible homogenization with bead beating tubes and ready-to-use lysing matrices for a wealth of sample types.
Choosing the right lysing matrix for homogenizing your cells, tissues, environmental samples, insects, and worms is easy with MP Bio’s comprehensive selection of Lysing Matrix tubes. Our innovative bead beating technologies come in a variety of bead sizes, shapes, and compositions to ensure complete homogenization, and the pre-loaded tubes deliver reproducible sample preparation from day-to-day and sample-to-sample.
All bead beating tubes are sterile and certified DNAse- and RNAse-free with standard sizes that fit just about any homogenizer on the market, including FastPrepâ„¢ instruments. All lysing matrix beads are washed and treated to remove microbial contamination.
- Easily maximize cell disruption with beads optimized for specific sample types (see table below)
- Avoid cross contamination with closed Lysing Matrix tubes
- Choose the best size for your workflow with 2 mL, 4.5 mL 15 mL, 50 mL tubes and 96-well plate options
- Use with any high-speed bead-beating homogenizer
- Validated worldwide with 3,000+ Lysing Matrix specific publications
Featured Product
A mixture of ceramic and silica particles designed to efficiently lyse cells in challenging environmental and fecal samples.
Lysing Matrix Tubes
Choose from a wide variety of high-quality lysing matrix options
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Learn MoreThe ABCs of Lysing Matrices
With a wide range of bead sizes, shapes, and compositions, MP Bio offers a dependable lysing matrix for every application.
Size
The smaller the particles used in the grinding media, the smaller the average particle size and the smaller the lowest-limiting particle size produced during pulverization. Matrix particle size should be selected based upon the size of the particles you wish to obtain in your lysate.
Shape
The shape of the grinding media is a major determining factor in how cells are disrupted. Dull media, such as spherical beads, utilize cascade impaction (hammering) as the main force for cell lysis. Sharp and angular shaped media will primarily generate mechanical shear forces (chopping and cutting) which can quickly open difficult cell walls, grind fibrous or elastic animal tissue, or crack spores or oocytes. Shear forces are preferable when isolating stable molecules such as DNA, stable proteins, structural polysaccharides and small molecules or metabolites. RNA and certain easily denatured proteins can be quickly degraded by shear forces, so care needs to be taken when using angular media. For isolation of these molecules, smooth impactor grinding media can be much more forgiving.
Hardness, Density, and Composition
The composition determines two very important qualities: hardness and density, both of which are inherent physical properties derived from the molecular composition of the matrix particle. The hardness must be greater than that of the sample being pulverized, with higher hardness values being more effective at disrupting hard and brittle cell membranes. Hardness and density values help optimize lysis efficiency while preserving the integrity of the analytes of interest.
