Cart
 
In Stock

Dextran sulfate sodium salt, colitis grade (36,000 - 50,000)

Dextran sulfate sodium salt, colitis grade (36,000 - 50,000)

¥6,700.00

Key features and details

  • Induces severe colitis (inflamatory bowel disease)
  • Highest sulfur content – 19%
  • Highest chirality - +104° of specific rotation
  • Lowest pH – 6.2 at 1% solution

SKU: 02160110-CF

Synonyms
DSS, Dextran Sodium Sulfate
CAS Number:
9011-18-1
Molecular Weight:
36,000 - 50,000 Da
MDL Number:
MFCD00081551
Product Description

Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research (see table below). One important property of DSS is to triggers colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. MP Premium Dextran Sulfate Sodium Salt (MW = 36,000–50,000) from MP Biomedicals is one of the most widely used product based on peer reviewed scientific publications. Over the past 15 years 3,000+ scientific publications have cited the use of our DSS.

Application Notes

Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.

MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).

Because of its high efficacy, MP Biomedical DSS is one of the most widely used DSS products in the scientific literature. Over the past 19 years more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Acute/ Chronic Ulcerative Colitis Model Induction, Chronic Colitis Associated Colon Cancer Model Induction

Specifications
SKU 02160110-CF
Alternate Names DSS, Dextran Sodium Sulfate
Application Notes

Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.

MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).

Because of its high efficacy, MP Biomedical DSS is one of the most widely used DSS products in the scientific literature. Over the past 19 years more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment.

Base Catalog Number 160110
Boiling Point 310 ° C
CAS # 9011-18-1
Grade Colitis Grade
Melting Point 92 ° C
Molecular Weight 36,000 - 50,000 Da
Personal Protective Equipment Eyeshields, Gloves, respirator filter
pH (1% aqueous solution) 5-7.11
References

Kinchen, J. Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease. Cell. 2018, 175, 372-386.


Mahalhal , A. Oral iron exacerbates colitis and influences the intestinal microbiome, PLOS ONE. 2018, 13, e0202460.


Dokoshi, T. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight. 2018, 3, e12307.


Zhu, H. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. J. Exp. Clin. Cancer Res. 2017, 36, 2.


Monticelli, L. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions. PNAS. 2015, 112, 10762-10767.

RTECS Number HH9290000
Solubility 100 mg/mL (decreases with increasing of MW)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 2.6 x 10-4 mm Hg at 25 ° C (Estimated)
Citations
Documents

Certificate of Analysis

Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis

Datasheet

Datasheet

Material Safety Datasheet

Material Safety Datasheet
en_AE
Material Safety Datasheet
de_AT
Material Safety Datasheet
en_AU
Material Safety Datasheet
fr_BE
Material Safety Datasheet
nl_BE
Material Safety Datasheet
en_CA
Material Safety Datasheet
fr_CA
Material Safety Datasheet
de_CH
Material Safety Datasheet
fr_CH
Material Safety Datasheet
it_CH
Material Safety Datasheet
zh_CN
Material Safety Datasheet
de_DE
Material Safety Datasheet
es_ES
Material Safety Datasheet
en_EU
Material Safety Datasheet
fi_FI
Material Safety Datasheet
fr_FR
Material Safety Datasheet
en_GB
Material Safety Datasheet
tw_HK
Material Safety Datasheet
en_ID
Material Safety Datasheet
en_IE
Material Safety Datasheet
en_IN
Material Safety Datasheet
it_IT
Material Safety Datasheet
ja_JP
Material Safety Datasheet
de_LI
Material Safety Datasheet
de_LU
Material Safety Datasheet
en_MT
Material Safety Datasheet
es_MX
Material Safety Datasheet
nl_NL
Material Safety Datasheet
no_NO
Material Safety Datasheet
pt_PT
Material Safety Datasheet
ru_RU
Material Safety Datasheet
sv_SE
Material Safety Datasheet
tw_TW
Material Safety Datasheet
en_US

Brochures

Application Notes

Case Studies