Streptozotocin

Name: Streptozotocin
SKU: 02100557-CF

$0.00

Key features and details

Streptozotocin

SKU: 02100557-CF

Synonyms

N-(Methylnitrosocarbamoyl)-α-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose

CAS Number:

18883-66-4

Molecular Formula:

C8H15N3O7

Molecular Weight:

265.222 g/mol

Beilstein Registry Number:

2060675

EC Number:

242-646-8

MDL Number:

MFCD00006607

Request A Custom or Bulk Quote

Product Description

Streptozotocin

Application Notes

Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Treatment of pancreatic (islet-cell) tumors

Specifications

SKU	02100557-CF
Alternate Names	N-(Methylnitrosocarbamoyl)-α-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
Application Notes	Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.
Base Catalog Number	100557
Beilstein Registry Number	2060675
Biochemical Physiological Actions	An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
CAS #	18883-66-4
EC Number	242-646-8
Extinction Coefficient	EmM(228 nm): 6.36 (ethanol)
Format	Powder
Half Life	biological half-life in cell culture medium was shown to be approximately 19 minutes.
Hazard Statements	H350
Melting Point	239Â° F (Decomposes) (NTP, 1992)
Molecular Formula	C8H15N3O7
Molecular Weight	265.222 g/mol
Personal Protective Equipment	Eyeshields, full-face particle respirator type N100, Gloves, respirator cartridge, respirator filter
Purity	~75% α-anomer basis; ≥97%
RTECS Number	LZ5775000
Safety Symbol	GHS06+GHS08
Solubility	Soluble (NTP, 1992)
Typical Working Concentration	Has been used in intravenous injections in rats at a dose of 65 mg/kg body weight to induce diabetes (using cold 0.1 M citrate buffer pH 4.5). In rats and dogs, diabetes was induced using intravenous dosage of 50 mg/kg body weight (using 1-2% w/v solutions in saline buffered with citrate dextrose solution at pH 5.0).
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.