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Product Description
Calpeptin is a cell permeable calpain inhibitor. Research shows that Calpeptin is an effective inhibitor of calpain 2 and can fully block cleavage of PLC-β 3 enzymes. Additionally, Calpeptin has demonstrated the ability to inhibit the activities of cathepsin L and calpain-1. In muscle cell studies Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. Pulmonary fibrosis research in mice have reported that Calpeptin can decrease expression of TGF-β1, IL-6, collage type Iα1, and angiopoietin-1 mRNA. Calpeptin is an inhibitor of Calpain 1, cathepsin K, cathepsin L and PTP. Calpeptin is an activator of Rock.
Application Notes
Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Inhibitor of Calpain and Cathepsin L
Specifications
| SKU | 0215956305 |
| Alternate Names | N-CBZ-L-Leucyl-Norleucinal, N-Benzyloxycarbonyl-L-leucylnorieucinal; Z-Leu-Nle-CHO |
| Applications | Inhibitor of Calpain and Cathepsin L |
| Application Notes | Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases. |
| Base Catalog Number | 15956305 |
| Biochemical Physiological Actions | Calpeptin is a rho kinase activator and an inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in apoptosis, long-term potentiation in neurons, and cell cycle progression. |
| CAS # | 117591-20-5 |
| Hazard Statements | H317 |
| Melting Point | 86 - 97 °C (Lit.) |
| Molecular Formula | C20H30N2O4 |
| Molecular Weight | 362.46 |
| Pack Size | 5 mg |
| Personal Protective Equipment | Respiratory protection: Breathing apparatus only if aerosol or dust is formed. Hand protection: Pvc or other plastic material gloves Skin and body protection: Usual safety precautions while handling the product will provide adequate protection against this potential effect. Eye protection: Safety glasses with side-shields Hygiene measures: Handle in accordance with good industrial hygiene and safety practice. |
| Solubility | Soluble in ethanol (25 mg/mL), DMSO (25 mg/mL) and DMF. |
| Typical Working Concentration | Effective concentration is typically 0.3 to 1.0 uM. Working solutions should be made fresh for each use. Dilute a 1 mM stock solution 1:1000 to obtain a 1 uM working solution. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Documents
Certificate of Analysis (COA)
![MP COA [159563] lot ID: 8637H](https://www.mpbio.com/static/version1790150415/frontend/Mpbio/luma/en_US/images/document.png "MP COA [159563] lot ID: 8637H")
Datasheet
Datasheet
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