Ribonuclease A (bovine)

Name: Ribonuclease A (bovine)
SKU: 02101076-CF
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SKU: 02101076-CF

Synonyms

Pancreatic Ribonuclease; RNase A; Ribonuclease I; Ribonucleate 3′ pyrimidinooligonucleotidohydrolase

CAS Number:

9001-99-4

Molecular Weight:

13700 (based on Amino acid sequence)

EC Number:

232-646-6

MDL Number:

MFCD00132181

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Specifications

SKU	02101076-CF
Alternate Names	Pancreatic Ribonuclease; RNase A; Ribonuclease I; Ribonucleate 3′ pyrimidinooligonucleotidohydrolase
Application Notes	Ribonuclease A, and to a greater extent its oligomers and some homologs (such as onconase from frogs), have cytotoxic and cytostatic effects, particularly on cancer cells.This attribute has led to the development of onconase as a cancer therapeutic.
Base Catalog Number	101076
Biochemical Physiological Actions	Ribonuclease A is an endoribonuclease that cleaves single stranded RNA after pyrimidine nucleotides. It attacks at the 3’ phosphate end. Ribonucleases do not hydrolyze DNA, because the DNA lacks 2'-OH groups essential for the formation of cyclic intermediates. RNase can also hydrolyze RNA from protein samples. RNase A can be inhibited by alkylation of His12 and His119 and activated by potassium and sodium salts.
CAS #	9001-99-4
EC Number	232-646-6
Extinction Coefficient	7.3 (280 nm) (Lit.)
Isoelectric Point	pH 9.45 (Lit.)
Molecular Weight	13700 (based on Amino acid sequence)
Personal Protective Equipment	Eyeshields, Gloves, Repirator Filter
pH	Optimum pH: 7.0 - 7.5
RTECS Number	RF0760000
Solubility	Dissolves readily at 2 mg/mL in analytical grade water to give a clear colorless solution.
Source	Bovine Pancreas
Specific Activity	≥50 Kunitz u/mg
Specificity	The enzyme is specific for pyrimidine nucleoside linkages; i.e.; those cleaving cyclic 2';3'-pyrimidine nucleotide residues either singly or at the termination of purine nucleotide chains.
Unit Definition	That amount of enzyme causing the hydrolysis of RNA at a rate such that k (velocity constant) equals unity at 25 °C and pH 5.0.
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.